Notre Dame never led in the contest.
Price and McGrew started the game with a pair of lay-ups to give Wesleyan a 4-0 advantage and the Bobcats were off and running.
Still leading by three at 10-7, Johnson and McGrew nailed short jumpers and Price put in a lay-up to extend Wesleyan's lead to 16-7 with 12:44 left in the first half.
Wesleyan opened up their biggest lead in the first half at 14 points, 33-19, after Anthony Richards (pictured) dropped in a three-pointer with 2:40 left in the half.
Notre Dame scored the last three baskets in the half to close the score to 33-27 at the intermission.
Wesleyan stormed out in the second half on fire as they went on a 21-6 run.
McGrew's jumper at the 11:19 mark pushed Wesleyan's lead to 21 at 54-33.
Wesleyan wasn't initially able to put Notre Dame away.
The Bobcats got sloppy with the ball and allowed Notre Dame to outscore them by a 27-15 margin to bring their deficit to single digits at eight, at 69-61, with three minutes remaining.
Notre Dame couldn't get any closer though as Wesleyan was solid at the free throw line down the stretch, outscoring the Falcons by an 11-3 margin in the final three minutes.
Wesleyan improved to 3-4 in the MEC and 5-8 overall.
They will return to action this Saturday against West Liberty. West Liberty is ranked No. 1 in the nation.
The game is scheduled for 4 p.m.