Casey shot a six-over 77 for the top spot in the 25-player field, with Brink right behind at seven over.
Becca Davis joined Casey and Brink in the top ten, placing seventh overall with an 85.
Wesleyan placed third overall as a team in the event with a score of 355.
Malone University of Ohio won the Open with a score of 337, followed by Alderson-Broaddus at 347. Ohio Valley was behind the Lady Bobcats at 367.